What is sodium thiosulfate used for?
Sodium thiosulfate, also spelled sodium thiosulphate, is used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. For cyanide poisoning it is often used after the medication sodium nitrite and typically only recommended for severe cases.
Can sodium thiosulfate harm you?
High blood pressure (hypertension) or. Kidney disease or. Liver disease or. Toxemia of pregnancy—Sodium thiosulfate may cause the body to retain (keep) water, which may make these conditions worse.
How do you take sodium thiosulfate?
For intravenous use. For single use only. Initial dose: 10 mL (300 mg) of sodium nitrite (rate of 2.5 to 5 mL/minute) should be administered intravenously, immediately followed by 50 mL (12.5 g) of sodium thiosulfate (rate of 5 mL/minute).
How do nitrates help cyanide poisoning?
The rationale for use of the cyanide antidote kit is that the nitrites produce methemoglobin (ferric hemoglobin) to which the cyanide combines to form cyanmethemoglobin, releasing the cyanide from the cytochrome.
Does sodium thiosulfate lower blood pressure?
What Are Side Effects Associated with Using Sodium Thiosulfate? Side effects of sodium thiosulfate include: Low blood pressure (hypotension) (infusion rate-dependent)
What does sodium thiosulfate do to the body?
Sodium nitrite and sodium thiosulfate is a combination medicine that is used as an antidote to cyanide poisoning. Sodium nitrite and sodium thiosulfate works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.
How quickly does sodium thiosulfate work?
Symptomatic relief and clinical improvement may occur within 2 weeks.
Which drug is used to treat cyanide poisoning caused by nitrates?
Hydroxocobalamin (HCO, vitamin B-12) is the first-line therapy for cyanide toxicity. It functions by binding cyanide to its cobalt ion to form cyanocobalamin, which is essentially nontoxic and is cleared renally.
Which nitrate is used in the treatment of cyanide poisoning?
The combination of sodium thiosulfate and sodium nitrite has been used in the United States since the 1930s as the primary antidote for cyanide intoxication.
Does cyanide bind to oxygen?
Toxicology Emergencies Patients with cyanide poisoning present with respiratory distress and normal oxygen saturation. Small amounts of cyanide bind to the ferrous ion on the hemoglobin molecule, which does not interfere with oxygen binding.